反应 #7527

反应方程式

2-chloro-4-methoxybenzyl alcohol

triethylamine

methanesulfonyl chloride

→

title compound

收率 61.0%

2-chloro-4-methoxybenzyl chloride

收率 61.0%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他The solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONthe obtained residue was dissolved in ethyl acetate
3. 3
   洗涤The organic layer was washed with saturated brine
4. 4
   干燥dried over anhydrous sodium sulfate
5. 5
   其他The solvent was evaporated under reduced pressure

实验过程

To a solution of 2-chloro-4-methoxybenzyl alcohol (1.5 g, 8.7 mmol) in dichloromethane (10 mL) were added under ice-cooling triethylamine (2.4 mL, 17.4 mmol) and methanesulfonyl chloride (0.74 mL, 9.5 mmol) and the mixture was stirred at room temperature for 2 h. The solvent was evaporated under reduced pressure and the obtained residue was dissolved in ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.01 g, 61%).

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