反应 #7526

反应方程式

2-chloro-4-methoxybenzaldehyde

sodium borohydride

→

title compound

收率 97.0%

2-chloro-4-methoxybenzyl alcohol

收率 97.0%

溶剂

methanol

反应条件

后处理

1. 1
   其他The solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONthe obtained residue was dissolved in ethyl acetate
3. 3
   洗涤The organic layer was washed with saturated brine
4. 4
   干燥dried over anhydrous sodium sulfate
5. 5
   其他The solvent was evaporated under reduced pressure

实验过程

To a solution of 2-chloro-4-methoxybenzaldehyde (1.55 g, 9 mmol) in methanol (20 mL) was added under ice-cooling sodium borohydride (378 mg, 10 mmol) and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure and the obtained residue was dissolved in ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.5 g, 97%).

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