反应 #75249

反应方程式

4-[4-Acetyl-7-(1-hydroxycyclohexyl)-6-heptyn-1-yl]benzoic acid

hydrogen

→

title compound

4-[4-Acetyl-7-(1-hydroxycyclohexyl)heptyl]benzoic Acid

溶剂

ethyl acetate

反应条件

后处理

1. 1
   其他at 1 atmosphere pressure and room temperature
2. 2
   过滤The catalyst is filtered off
3. 3
   其他the solvent is evaporated
4. 4
   其他the residue (5 g.) is chromatographed on 75 g

实验过程

4-[4-Acetyl-7-(1-hydroxycyclohexyl)-6-heptyn-1-yl]benzoic acid (5.1 g., 0.014 mole) in ethyl acetate (55 ml.) is hydrogenated over 2.0 g. of a 5% Pt on charcoal catalyst at 1 atmosphere pressure and room temperature. The theoretical amount of hydrogen (0.028 mole) is absorbed in 25 minutes. The catalyst is filtered off, the solvent is evaporated and the residue (5 g.) is chromatographed on 75 g. of silica gel with 2% methanol in chloroform as eluant. The title compound is obtained as a colorless viscous oil.

来源