反应 #7511

反应方程式

water

ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

potassium carbonate

4-fluorobenzylbromide

→

title compound

收率 79.2%

ethyl 2-(2,3-dihydro-1H-indol-1-yl)-4-[(4-fluorobenzyl)oxy]-5-pyrimidinecarboxylate

收率 79.2%

溶剂

N,N-dimethylformamide

反应条件

后处理

1. 1
   温度to cool to room temperature
2. 2
   过滤The precipitated crystals were collected by filtration
3. 3
   洗涤washed several times with cold water and cold ether
4. 4
   其他dried

实验过程

To a solution of ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (7.1 g, 27.6 mmol) in N,N-dimethylformamide (100 ml) were added potassium carbonate (7.8 g, 60 mmol) and 4-fluorobenzylbromide (3.74 ml, 30 mmol) and the mixture was stirred at 80° C. for 18 h. The reaction mixture was allowed to cool to room temperature and water was added. The precipitated crystals were collected by filtration, washed several times with cold water and cold ether and dried to give the title compound (8.6 g, 79%).

来源