反应 #74844

反应方程式

2-(p-fluorobenzoyl)-3-dimethylaminocrotononitrile

HCl

methanol

→

2-(p-Fluorobenzoyl)-3-hydroxycrotononitrile

反应条件

后处理

1. 1
   温度Upon cooling in an ice bath
2. 2
   其他a solid formed
3. 3
   其他was collected
4. 4
   其他recrystallized from cyclohexane-petroleum ether with charcoal treatment
5. 5
   其他giving 0.7 g

实验过程

A solution of 1.35 g. (0.006 m) of 2-(p-fluorobenzoyl)-3-dimethylaminocrotononitrile in a mixture of 15 ml. methanol and 8 ml. of 1 N HCl was heated on the steam bath in an open beaker for 45 minutes. Upon cooling in an ice bath, a solid formed, was collected, and then recrystallized from cyclohexane-petroleum ether with charcoal treatment, giving 0.7 g. (64%) of light pinkish crystals, m.p. 65°-67° C.

来源