反应 #74743

反应方程式

DMSO

2-Chloro-5-nitropyridine

2,2,2-trifluoroethanol

lithium hydroxide

→

2-(2,2,2-Trifluoroethoxy)-5-Nitropyridine

溶剂

water

反应条件

后处理

1. 1
   其他the product was separated by filtration
2. 2
   其他It was crystallized from ethyl acetate-hexanes, yield 5.0 grams
3. 3
   其他35°-37° C.

实验过程

2-Chloro-5-nitropyridine (9.5 grams), 2,2,2-trifluoroethanol (6.0 grams), and lithium hydroxide (4.0 grams) were mixed in 50 ml. of DMSO and stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into water and the product was separated by filtration. It was crystallized from ethyl acetate-hexanes, yield 5.0 grams, m.p., 35°-37° C.

来源