反应 #7459

反应方程式

water

4-bromobenzyl alcohol

diisopropylethylamine

chloromethyl methyl ether

→

1-bromo-4-[(methoxymethyloxy)methyl]benzene

收率 86.7%

溶剂

dichloromethane

反应条件

后处理

1. 1
   萃取the mixture was extracted diethyl ether
2. 2
   洗涤The organic layer was washed with water
3. 3
   干燥dried over anhydrous magnesium sulfate
4. 4
   其他the solvent was removed under reduced pressure
5. 5
   其他The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/1)

实验过程

To a solution of 4-bromobenzyl alcohol (2.8 g) and diisopropylethylamine (2.5 g) in dichloromethane (30 mL) was added chloromethyl methyl ether (1.3 g) at 0° C., and the mixture was stirred at room temperature for 14 hours. To the reaction mixture was water, and the mixture was extracted diethyl ether. The organic layer was washed with water and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/1) to give 1-bromo-4-[(methoxymethyloxy)methyl]benzene (3.0 g).

来源