反应 #74503

反应方程式

water

2,4-dichlorobenzoic acid

compound 80

2,4-dichlorobenzoic acid

bromine

→

title compound

收率 187.5%

5-Bromo-2,4-dichlorobenzoic acid

收率 187.5%

溶剂

chlorosulfonic acid

反应条件

后处理

1. 1
   温度cooled to ambient temperature
2. 2
   其他The resulting solid was isolated by filtration
3. 3
   其他dried in vacuo

实验过程

To a solution of 2,4-dichlorobenzoic acid (compound 80, 25.0 g, 131 mmol) in chlorosulfonic acid (100 mL) was added bromine (3.4 mL, 65 mmol) and sulfur (0.20 g, 6.6 mmol). The reaction mixture was stirred at 70° C. overnight and then cooled to ambient temperature. The reaction mixture was poured into iced water. The resulting solid was isolated by filtration and dried in vacuo to yield title compound (32.9 g, 93%) as pale brown solid.

来源