反应 #7434

反应方程式

water

2-(N-ethylanilino)ethanol

triethylamine

acetyl chloride

→

2-(ethylphenylamino)ethyl acetate

收率 99.9%

溶剂

acetone

反应条件

后处理

1. 1
   workup.STIRRINGThis mixture was stirred for 3 hours at room temperature
2. 2
   萃取An organic layer was extracted with ethyl acetate
3. 3
   洗涤washed with water
4. 4
   干燥dried over sodium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

实验过程

51.8 g of 2-(N-ethylanilino)ethanol and 31.7 g of triethylamine were dissolved in 320 ml of acetone, and to this solution 24.9 g of acetyl chloride was slowly added dropwise while stirring under ice cooling. This mixture was stirred for 3 hours at room temperature, and the reaction solution was poured into 500 ml of water. An organic layer was extracted with ethyl acetate, washed with water, and then dried over sodium sulfate. The solvent was distilled off under reduced pressure to obtain 64.9 g of 2-(ethylphenylamino)ethyl acetate.

来源