反应 #74274

反应方程式

N-((1-benzyl-4-(4-cyclopropylpiperazin-1-yl)-piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

acetic acid

hydrogen

→

desired product

收率 90.0%

N-((4-(4-Cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide

收率 90.0%

溶剂

methanol

反应条件

后处理

1. 1
   其他for 10 min
2. 2
   过滤The reaction mixture was filtered through celite
3. 3
   浓缩the filtrate was concentrated to dryness

实验过程

Through a solution of N-((1-benzyl-4-(4-cyclopropylpiperazin-1-yl)-piperidin-4-yl)methyl)-2,2,2-trifluoroacetamide (5.4 mmol) in methanol (30 ml) was passed argon gas for 10 min. Then acetic acid (855 μl) and Pd(OH)2 (40% by weight) were added to the reaction mixture and it was stirred at room temperature for 16 h under an atmosphere of H2 by using a hydrogen balloon. The reaction mixture was filtered through celite and the filtrate was concentrated to dryness to yield the desired product which was used in the next step without further purification. Yield: 90%.

来源