反应 #742322

反应方程式

(1S,3S)-N-[3-(2-pyridyl)cyclopentyl]phthalimide

→

(1S,3S)-3-(2-pyridyl)cyclopentylamine

收率 92.0%

溶剂

EtOH

反应条件

后处理

1. 1
   温度at reflux for 3 h
2. 2
   温度After cooling
3. 3
   过滤the reaction mixture was filtered
4. 4
   其他followed by the removal of solvent
5. 5
   workup.STIRRINGstirred
6. 6
   温度at reflux for 1 h
7. 7
   温度After cooling
8. 8
   过滤the precipitate was filtered
9. 9
   其他followed by the removal of solvent

实验过程

A mixture of (1S,3S)-N-[3-(2-pyridyl)cyclopentyl]phthalimide (4.12 g, 14.1 mmol), and hydrazinemonohydorate (2.0 mL, 41.2 mmol) in EtOH (100 mL) was stirred at reflux for 3 h. After cooling, the reaction mixture was filtered followed by the removal of solvent. The residue was suspended in EtOAc and stirred at reflux for 1 h. After cooling, the precipitate was filtered followed by the removal of solvent to yield (1S,3S)-3-(2-pyridyl)cyclopentylamine (2.10 g, 92%) as yellow oil.

来源