反应 #742319

反应方程式

3-(2-pyridyl)-2-cyclopenten-1-one

→

3-(2-pyridyl)cyclopentan-1-one

溶剂

EtOH

反应条件

后处理

1. 1
   其他The catalyst was removed by filtration over Celite
2. 2
   浓缩the filtrate was concentrated in vacuo
3. 3
   其他The crude product was purified by column chromatography (Hexane/EtOAc=1/1)

实验过程

A mixture of 3-(2-pyridyl)-2-cyclopenten-1-one (1.43 g, 8.98 mmol) and 10% Pd/C (142 mg) in EtOH (30 mL) was stirred under hydrogen atmosphere (0.3 MPa) for 6.5 h. The catalyst was removed by filtration over Celite and the filtrate was concentrated in vacuo. The crude product was purified by column chromatography (Hexane/EtOAc=1/1) to yield 3-(2-pyridyl)cyclopentan-1-one (3.26 g, 94%) as colorless oil.

来源