反应 #742314

反应方程式

{1-[(1S,4R)-4-(2,6-dichloro purin-9-yl)-cyclopent-2-enyl]-1H-pyrazol-4-yl}-methanol

diphenylethylamine

DIPEA

→

title product

(1-{(1S,4R)-4-[2-Chloro-6-(2,2-diphenylethylamino)-purin-9-yl]-cyclopent-2-enyl}-1H-pyrazol-4-yl)-methanol

溶剂

THF

反应条件

后处理

1. 1
   其他The solvent is removed in vacuo
2. 2
   其他the resulting crude residue is partitioned between DCM and 0.1 M HCl
3. 3
   其他The organic portion is separated
4. 4
   洗涤washed with water, brine
5. 5
   干燥dried (MgSO4)
6. 6
   浓缩concentrated in vacuo

实验过程

A mixture comprising {1-[(1S,4R)-4-(2,6-dichloro purin-9-yl)-cyclopent-2-enyl]-1H-pyrazol-4-yl}-methanol (0.675 g, 1.92 mmol), diphenylethylamine (0.398 g, 2.02 mmol) and DIPEA (0.298 g, 2.31 mmol) in dry THF (20 mL) is stirred at 35 C for 3 days. The solvent is removed in vacuo and the resulting crude residue is partitioned between DCM and 0.1 M HCl. The organic portion is separated, washed with water, brine, dried (MgSO4) and concentrated in vacuo to afford the title product.

来源