反应 #742309
ord-e74c1ac093104f9093d6dc1cb4fe8bf3
反应方程式
1-{(R)-1-[9-[(2R,3R,4S,5R)-5-(2-Benzyl-2H-tetrazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea
ammonium formate
→
title compound
1-((R)-1-[9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(2H-tetrazol-5-yl)-tetrahydro-furan-2-yl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea
反应物
溶剂
反应条件
温度
50°CELSIUS
详细条件
See reaction.notes.procedure_details.
后处理
- 1过滤filtered through Celite®
- 2浓缩The filtrate is concentrated in vacuo
实验过程
A solution of 1-{(R)-1-[9-[(2R,3R,4S,5R)-5-(2-Benzyl-2H-tetrazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea in EtOH under an inert atmosphere of argon is treated with 10% palladium on carbon followed by ammonium formate. The reaction mixture is heated to 50° C. for 4 hours and then filtered through Celite®. The filtrate is concentrated in vacuo to afford the title compound.