反应 #742307

ord-3c269b48a2f8459f96d619355dd99ad8

反应方程式

N[C@H](CO)Cc1ccccc1
(S)-2-amino-3-phenyl-propan-1-ol
O[C@@H]1[C@H](O)[C@@H](c2nnn(Cc3ccccc3)n2)O[C@H]1n1cnc2c(NCC(c3ccccc3)c3ccccc3)nc(Cl)nc21
(2R,3S,4R,5R)-2-(2-benzyl-2H-tetrazol-5-yl)-5-[2-chloro-6-(2,2-diphenylethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol
→
OC[C@H](Cc1ccccc1)Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](c2nnn(Cc3ccccc3)n2)[C@@H](O)[C@H]1O
title compound
OC[C@H](Cc1ccccc1)Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](c2nnn(Cc3ccccc3)n2)[C@@H](O)[C@H]1O
(2R,3R,4S,5R)-2-[6-((S)-1-Benzyl-2-hydroxyethylamino)-2-chloro-purin-9-yl]-5-(2-benzyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol

反应物

N[C@H](CO)Cc1ccccc1
(S)-2-amino-3-phenyl-propan-1-ol
O[C@@H]1[C@H](O)[C@@H](c2nnn(Cc3ccccc3)n2)O[C@H]1n1cnc2c(NCC(c3ccccc3)c3ccccc3)nc(Cl)nc21
(2R,3S,4R,5R)-2-(2-benzyl-2H-tetrazol-5-yl)-5-[2-chloro-6-(2,2-diphenylethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

The title compound is prepared in an analogous fashion to (2R,3S,4R,5R)-2-(2-benzyl-2H-tetrazol-5-yl)-5-[2-chloro-6-(2,2-diphenylethylamino)-purin-9-yl]-tetrahydro-furan-3,4-diol (WO 99/38877) by replacing 2,2-diphenylethylamine with (S)-2-amino-3-phenyl-propan-1-ol

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08071565B2uspto-grants-2011_12