反应 #742306
ord-3538dcc5a38f41d6a5ab7c6d7162e663
反应方程式
4,4′-(2-aminoethylidene)bisphenol
acetic acid (2R,3R,4R,5S)-4-acetoxy-5-(3-acetoxymethyl-isoxazol-5-yl)-2-(2,6-dichloro-purin-9-yl)-tetrahydro-furan-3-yl ester
Intermediate A
4,4′-(2-aminoethylidene)bisphenol
→
title compound
(2R,3R,4S,5S)-2-{6-[2,2-bis(4-Hydroxy-phenyl)-ethylamino]-2-chloro-purin-9-yl}-5-(3-hydroxymethyl-isoxazol-5-yl)-tetrahydrofuran-3,4-diol
反应物
试剂
无
反应条件
详细条件
See reaction.notes.procedure_details.
实验过程
The title compound is prepared from acetic acid (2R,3R,4R,5S)-4-acetoxy-5-(3-acetoxymethyl-isoxazol-5-yl)-2-(2,6-dichloro-purin-9-yl)-tetrahydro-furan-3-yl ester (WO 99/38877) analogously to (2R,3R,4S,5S)-2-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-(3-hydroxymethyl-isoxazol-5-yl)-tetrahydro-furan-3,4-diol (Intermediate CG) by replacing 2,2-diphenylethylamine with 4,4′-(2-aminoethylidene)bisphenol (Intermediate A).