反应 #742301

反应方程式

Phenyl chloroformate

3-aminopyridine

→

titled compound

Pyridin-3-yl-carbamic acid phenyl ester

溶剂

DCM

pyridine DCM

反应条件

后处理

1. 1
   workup.ADDITIONis added dropwise
2. 2
   其他The solvent is removed in vacuo
3. 3
   workup.DISSOLUTIONthe residue is dissolved in ethyl acetate
4. 4
   洗涤This organic portion is washed with 0.1 M HCl
5. 5
   浓缩concentrated in vacuo

实验过程

Phenyl chloroformate (0.733 mL, 5.84 mmol) is suspended in pyridine/DCM (3 mL, 2:1). The solution is stirred at 0° C., and 3-aminopyridine (500 mg, 5.31 mmol) dissolved in DCM (1 mL) is added dropwise. The reaction mixture is at 0° C. for 1 hour. The solvent is removed in vacuo and the residue is dissolved in ethyl acetate. This organic portion is washed with 0.1 M HCl and then concentrated in vacuo to afford the titled compound. (MH+215)

来源