反应 #742276

ord-8a93aaca8cfb4bda82219c51c57b8cd5

反应方程式

Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
ATP
O=P(O)(O)OC[C@H]1O[C@H](OP(=O)(O)OP(=O)(O)O)[C@H](O)[C@@H]1O
PRPP
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
adenosine-5′-triphosphate
O=P(O)(O)OC[C@H]1O[C@H](OP(=O)(O)OP(=O)(O)O)[C@H](O)[C@@H]1O
PRPP
N[C@@H](Cc1c[nH]cn1)C(=O)O
histidine
N[C@@H](Cc1c[nH]cn1)C(=O)O
histidine
→
N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
tryptophan

反应物

Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
ATP
O=P(O)(O)OC[C@H]1O[C@H](OP(=O)(O)OP(=O)(O)O)[C@H](O)[C@@H]1O
PRPP
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
adenosine-5′-triphosphate
O=P(O)(O)OC[C@H]1O[C@H](OP(=O)(O)OP(=O)(O)O)[C@H](O)[C@@H]1O
PRPP
N[C@@H](Cc1c[nH]cn1)C(=O)O
histidine
N[C@@H](Cc1c[nH]cn1)C(=O)O
histidine
—
5-Phosphoribosyl-α-1-pyrophosphate

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

5-Phosphoribosyl-α-1-pyrophosphate (hereinafter, “PRPP”) and adenosine-5′-triphosphate (hereinafter, “ATP”) are the initial substrates in histidine biosynthesis. PRPP can sometimes induce the histidine biosynthesis to follow divergent pathways, resulting in the biosynthesis of pyrimidine nucleotides, purine nucleotides, pyridine nucleotides, and tryptophan (Escherichia coli and Salmonella, Second Edition, Editor in Chief: F. C. Neidhardt, ASM Press, Washington D.C., 1996).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08071339B2uspto-grants-2011_12