反应 #742258

反应方程式

3-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid tert-butyl-dimethyl-silyl ester

oxalyl chloride

→

3-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-acryloyl chloride

溶剂

CH2Cl2

反应条件

后处理

1. 1
   workup.ADDITIONAfter complete addition the reaction mixture
2. 2
   过滤The reaction mixture was filtered
3. 3
   其他evaporated to dryness
4. 4
   温度The solution was cooled in the refrigerator overnight
5. 5
   过滤filtered
6. 6
   其他evaporated

实验过程

To a 0° C. cold solution of 6.3 g of 3-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-acrylic acid tert-butyl-dimethyl-silyl ester and 8 drops of DMF in 15 ml of CH2Cl2 was added dropwise 2.0 ml of oxalyl chloride. After complete addition the reaction mixture was allowed to warm to room temperature and stirring was continued for 60 h. The reaction mixture was filtered, evaporated to dryness and taken up in MTBE. The solution was cooled in the refrigerator overnight, filtered and evaporated to yield 4.4 g of 3-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-acryloyl chloride.

来源