反应 #742251

反应方程式

3-(2-hydroxy-phenyl)-acrylic acid ethyl ester

potassium hydroxide

→

colourless crystals

收率 51.9%

(E)-3-(2-Hydroxy-phenyl)-acrylic acid

收率 51.9%

溶剂

ethanol

water

反应条件

后处理

1. 1
   温度at reflux for 28 hours
2. 2
   浓缩the reaction mixture was concentrated
3. 3
   workup.ADDITIONThe residue was diluted with 500 ml HCl 2N
4. 4
   萃取extracted with ether
5. 5
   洗涤The organic phase was washed with 2N HCl and water
6. 6
   其他dried
7. 7
   其他evaporated to dryness
8. 8
   其他The resulting solid was recrystallized

实验过程

To a solution of 100.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester in 500 ml of ethanol, a solution of 50.9 g potassium hydroxide in 500 ml of water was dropped in at room temperature. After stirring at reflux for 28 hours, the reaction mixture was concentrated. The residue was diluted with 500 ml HCl 2N and extracted with ether. The organic phase was washed with 2N HCl and water, dried and evaporated to dryness. The resulting solid was recrystallized to yield 44.3 g of colourless crystals.

来源