反应 #742249

反应方程式

ethoxycarbonylmethylenetriphenylphosphorane

toluene

1-(4-diethylamino-2-hydroxy-phenyl)ethanone

→

3(4-Diethylamino-2-hydroxy-phenyl)-but-2-enoic acid ethyl ester

反应条件

后处理

1. 1
   温度Then the reaction mixture was heated to reflux
2. 2
   温度After refluxing for 31 hours the mixture
3. 3
   温度was cooled down
4. 4
   其他evaporated to dryness
5. 5
   其他The resulting dark oil was purified by chromatography
6. 6
   其他to yield a colourless oil

实验过程

To a suspension of 5.27 g ethoxycarbonylmethylenetriphenylphosphorane in 10 ml of toluene, a solution of 2.02 g 1-(4-diethylamino-2-hydroxy-phenyl)ethanone (DE 28 44 606) was dropped in at room temperature. Then the reaction mixture was heated to reflux. After refluxing for 31 hours the mixture was cooled down and evaporated to dryness. The resulting dark oil was purified by chromatography to yield a colourless oil.

来源