反应 #74072

反应方程式

Ethyl 8-(methylsulfanyl)-1-trityl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

trifluoroacetic acid

→

title compound

收率 96.0%

Ethyl 8-(methylsulfanyl)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate

收率 96.0%

溶剂

DCM

反应条件

后处理

1. 1
   其他the solvent removed in vacuo
2. 2
   其他The residue was triturated with diethyl ether
3. 3
   过滤filtered
4. 4
   其他dried

实验过程

Ethyl 8-(methylsulfanyl)-1-trityl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate (1.0 g, 1.99 mmol) in DCM (20 ml) was treated with trifluoroacetic acid (5 ml). The resulting mixture was stirred at r.t. for 1 hour and the solvent removed in vacuo. The residue was triturated with diethyl ether filtered and dried to provide the title compound 500 mg (96%). LC/MS (254 nm) HPLC method 2 Rt 3.62 min.

来源