反应 #73984

反应方程式

methacryloyl chloride

trimethylsilyl propyn-1-ol

Et3N

→

2-Methyl-acrylic acid 3-trimethylsilanyl-prop-2-ynyl ester

溶剂

Et2O

Et2O

反应条件

后处理

1. 1
   其他Any precipitated ammonium salts can be removed by filtration, and volatile components
2. 2
   其他can be removed under reduced pressure
3. 3
   其他The crude product is then purified by flash chromatography

实验过程

A solution of trimethylsilyl propyn-1-ol (1 g, 7.8 mmol) and Et3N (1.4 mL, 10 mmol) in Et2O (10 mL) is cooled to −20° C. and a solution of methacryloyl chloride (0.9 mL, 9.3 mmol) in Et2O (5 mL) is added dropwise over 1 h. The mixture is stirred at this temperature for 30 min, and then allowed to warm to ambient temperature overnight. Any precipitated ammonium salts can be removed by filtration, and volatile components can be removed under reduced pressure. The crude product is then purified by flash chromatography.

来源