反应 #73578

反应方程式

metformin hydrochloride

sodium acetate trihydrate

→

metformin acetate

收率 51.6%

溶剂

water

反应条件

后处理

1. 1
   过滤Then the resulting crystal was filtered
2. 2
   洗涤washed with acetone
3. 3
   其他dried at 60° C.

实验过程

20.0 g (1 equivalent) of metformin hydrochloride, 50 Ml of water, and 19.72 g (1.2 equivalents) of sodium acetate trihydrate were added to a reactor, and stirred. Then the resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 11.72 g of metformin acetate (yield: 51.3%).

来源