反应 #7326

反应方程式

Pyridine

cyanuric fluoride

FMOC-L-Leucine

→

FMOC-L-leucyl fluoride

溶剂

acetonitrile

反应条件

后处理

1. 1
   过滤the resulting slurry was filtered
2. 2
   workup.ADDITIONThe filtrate was poured into a separatory funnel
3. 3
   其他the layers were separated
4. 4
   干燥The organic layer was dried over anhydrous sodium sulfate
5. 5
   过滤filtered
6. 6
   浓缩concentrated under reduced pressure

实验过程

FMOC-L-Leucine (5 g, 14.14 mmol) (Bachem) was dissolved in acetonitrile (70 mL). Pyridine (1.14 mL, 14.14 mmol) (Aldrich) and cyanuric fluoride (1.91 g, 14.14 mmol) (Aldrich) were successively added at room temperature and the mixture was stirred overnight. Ice cold water (300 mL) was added and the resulting slurry was filtered. The filtrate was poured into a separatory funnel and the layers were separated. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford FMOC-L-leucyl fluoride as a white powder. (Yield 4.57 g, 91%).

来源