反应 #7312

反应方程式

5-chlorobenzotriazole

chloroacetone

potassium carbonate

potassium iodide

→

1-(5-chlorobenzotriazol-1-yl)-propan-2-one

1-(6-chlorobenzotriazol-1-yl)-propan-2-one

溶剂

acetone

反应条件

后处理

1. 1
   过滤The mixture is subsequently filtered
2. 2
   浓缩the filtrate concentrated by evaporation in a vacuum
3. 3
   其他the residue purified by flash chromatography

实验过程

A mixture of 5 g of 5-chlorobenzotriazole, 1.4 g of chloroacetone, 5.1 g of potassium carbonate and 0.5 g of potassium iodide is stirred into 50 ml of acetone at room temperature for 48 h. The mixture is subsequently filtered, the filtrate concentrated by evaporation in a vacuum, and the residue purified by flash chromatography. In this way, two isomeric products, 1-(5-chlorobenzotriazol-1-yl)-propan-2-one and 1-(6-chlorobenzotriazol-1-yl)-propan-2-one, are isolated in approximately the same quantities, the first of which is then used directly in the next step.

来源