反应 #7281

反应方程式

4-hydroxymethyl-benzaldehyde

2-aminopyridine

acetic acid

sodium triacetoxyborohydride

→

title compound

收率 74.0%

[4-(Pyridin-2-ylaminomethyl)-phenyl]-methanol

收率 74.0%

溶剂

THF

反应条件

后处理

1. 1
   其他one hour at 50° C., followed by purification of crude material

实验过程

Using general procedure B: Reaction of 4-hydroxymethyl-benzaldehyde (1.01 g, 7.42 mmol), 2-aminopyridine (697 mg, 7.42 mmol), acetic acid (0.5 mL) and sodium triacetoxyborohydride (3.2 g, 14.8 mmol) in THF (20 mL) at room temperature under N2 for 40 min., then one hour at 50° C., followed by purification of crude material using chromatography on silica gel (2:2:96 CH3OH—NH3 H2O—CH2Cl2), afforded the title compound (1.17 g, 74%) as white foam.

来源