反应 #725897

反应方程式

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester

→

23

收率 71.1%

[2-(4-Amino-phenoxy)-ethoxy]-acetic acid methyl ester

收率 71.1%

溶剂

ethyl acetate

反应条件

后处理

1. 1
   过滤The catalyst was filtered
2. 2
   浓缩the filtrate concentrated
3. 3
   workup.ADDITIONhexane (3 ml) added
4. 4
   过滤the solid filtered

实验过程

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester 22 (1 g, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 ml), palladium carbon (10%, 0.1 g) added and the mixture stirred under an atmosphere of hydrogen using balloon for 30 minutes. The catalyst was filtered, the filtrate concentrated, hexane (3 ml) added, and the solid filtered to give 23 (625 mg, 70.9%) as a light brown powder. The melting point was found to be 51-52.5° C. The structure was confirmed with IR and NMR.

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