反应 #725894

反应方程式

6-(4-Acetylaminophenoxy)hexanoic acid methyl ester

6-(4-Acetylamino-phenoxy)-hexanoic acid methyl ester

hydrochloric acid

→

20

收率 55.6%

6-(4-Amino-phenoxy)-hexanoic acid Hydrochloride

收率 55.6%

反应条件

后处理

1. 1
   温度was refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   过滤filtered hot
4. 4
   过滤filtered
5. 5
   其他dried

实验过程

A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.

来源