反应 #7240

反应方程式

2-(hydroxymethyl)-3-methylpyridine

→

3-methylpyridine-2-carboxaldehyde

收率 64.0%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   过滤then filtered through celite
2. 2
   浓缩The filtrate was concentrated

实验过程

To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.

来源