反应 #7221

反应方程式

N-benzimidazolyl-1,2-propanediol

sodium periodate

→

2-(benzimidazol-1-yl)-ethanal

收率 41.2%

溶剂

water

反应条件

后处理

1. 1
   萃取The solution was then extracted with dichloromethane
2. 2
   干燥dried (MgSO4)
3. 3
   过滤filtered
4. 4
   浓缩concentrated

实验过程

The intermediate, N-benzimidazolyl-1,2-propanediol (0.66 g, 3.4 mmol) from above was dissolved in water (25 mL) and treated with sodium periodate (0.88 g, 4.1 mmol) with stirring for 1.5 hours. The solution was then extracted with dichloromethane, dried (MgSO4), filtered and concentrated to yield 2-(benzimidazol-1-yl)-ethanal (0.22 g, 1.4 mmol) which was used immediately without further purification in the next reaction.

来源