反应 #721857

反应方程式

5-Benzyloxy-2-fluoro-4-methyl-1-nitrobenzene

hydrazine hydrate

→

5-benzyloxy-2-fluoro-4-methylaniline

收率 100.1%

溶剂

methanol

methanol

反应条件

后处理

1. 1
   温度heated
2. 2
   温度at reflux
3. 3
   温度The mixture was maintained
4. 4
   温度under reflux for 15 minutes
5. 5
   其他the insoluble materials removed by filtration through diatomaceous earth
6. 6
   洗涤The filter pad was washed with methanol
7. 7
   其他the solvent removed from the filtrate by evaporation

实验过程

5-Benzyloxy-2-fluoro-4-methyl-1-nitrobenzene (500 mg, 1.9 mmol) in methanol (10 ml) was added to a suspension of Raney nickel (75 mg) and hydrazine hydrate (465 ml, 9.5 mmol) in methanol (10 ml) and heated at reflux. The mixture was maintained under reflux for 15 minutes and then the insoluble materials removed by filtration through diatomaceous earth. The filter pad was washed with methanol and the solvent removed from the filtrate by evaporation to give 5-benzyloxy-2-fluoro-4-methylaniline (440 mg, 99%).

来源