反应 #721856

反应方程式

4-fluoro-2-methyl-5-nitrophenol

benzyl bromide

potassium carbonate

→

5-benzyloxy-2-fluoro-4-methyl-1-nitrobenzene

收率 90.7%

溶剂

DMF

water

反应条件

后处理

1. 1
   其他(prepared
2. 2
   温度to cool
3. 3
   过滤The precipitated product was collected by filtration
4. 4
   洗涤washed with water
5. 5
   其他dried

实验过程

A mixture of 4-fluoro-2-methyl-5-nitrophenol (4.69 g, 27 mmol), (prepared as described for the starting material in Example 8), benzyl bromide (3.59 ml, 30 mmol) and potassium carbonate (7.58 g, 55 mmol) in DMF (100 ml) was heated at 80° C. for 4 hours. The reaction mixture was allowed to cool and diluted with water and stirred for 15 minutes. The precipitated product was collected by filtration, washed with water and dried to give 5-benzyloxy-2-fluoro-4-methyl-1-nitrobenzene (6.4 g, 89%).

来源