反应 #72110

反应方程式

ethyl 3-(4-tert-butoxycarbonylaminocyclohex-1-enyl)benzoate

→

title compound

收率 57.8%

Ethyl 3-(4-aminocyclohex-1-enyl)benzoate

收率 57.8%

溶剂

hydrochloric acid 1,4-dioxane

反应条件

后处理

1. 1
   其他the solvent was evaporated under reduced pressure
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in methanol
3. 3
   workup.ADDITIONAmberlite IRA-400(Cl) ion exchange resin (20 g) was added
4. 4
   workup.STIRRINGthe mixture was stirred at room temperature for one hour
5. 5
   过滤Amberlite was filtered off
6. 6
   浓缩the solution was concentrated under reduced pressure

实验过程

A 4 N hydrochloric acid/1,4-dioxane solution (20 mL) was added to ethyl 3-(4-tert-butoxycarbonylaminocyclohex-1-enyl)benzoate obtained in Example (195b) (510 mg, 1.48 mmol). The mixture was stirred at room temperature for one hour, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in methanol. Amberlite IRA-400(Cl) ion exchange resin (20 g) was added, and the mixture was stirred at room temperature for one hour. Amberlite was filtered off, and then the solution was concentrated under reduced pressure to obtain 210 mg of the title compound as a colorless oily substance.

来源