反应 #7206

反应方程式

2-bromo-1-(3-methoxy-phenyl)-ethanone

formamide

CH2Cl2 MeOH NH4OH

→

title compound

收率 43.0%

5-(3-Methoxy-phenyl)-1H-imidazole

收率 43.0%

反应条件

实验过程

Reaction of 2-bromo-1-(3-methoxy-phenyl)-ethanone (2.5 g, 10.90 mmol), and formamide (3.1 mL, 76.40 mmol), followed by chromatography (CH2Cl2/MeOH/NH4OH 48:1:1) gave the title compound (820 mg, 43%) as a white solid. 1H NMR (300 MHz, CD3OD) δ 3.83 (s, 3H), 6.78–6.82 (m, 1H), 7.26–7.28 (m, 3H), 7.42 (s, 1H), 7.72 (s, 1H).

来源