反应 #71793

反应方程式

ammonium formate

Ethyl cis(±)-[2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-thiazol-4-yl]acetate

→

Ethyl cis(±)-[2-(4-amino-3-methoxypiperidin-1-yl)-1,3-thiazol-4-yl]acetate

溶剂

ethanol

反应条件

后处理

1. 1
   温度the mixture was heated
2. 2
   温度under reflux for 15 hours
3. 3
   过滤The reaction solution was filtered through celite
4. 4
   洗涤The filtrate was washed with saturated sodium bicarbonate
5. 5
   干燥dried over anhydrous sodium sulfate
6. 6
   浓缩concentrated under reduced pressure
7. 7
   其他The resulting compound was used for the next reaction without purification

实验过程

Ethyl cis(±)-[2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-thiazol-4-yl]acetate obtained in Example (64c) (124 mg, 0.29 mmol) was dissolved in ethanol (5 mL). A 10% palladium-carbon catalyst (75 mg) and ammonium formate (90 mg, 1.43 mmol) were added, and the mixture was heated under reflux for 15 hours. The reaction solution was filtered through celite. The filtrate was washed with saturated sodium bicarbonate, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

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