反应 #71532

反应方程式

NaOH

cyclohexanecarbaldehyde

2,2-diethoxyethylamine

Sodium triacetoxyborohydride

→

N-cyclohexylmethyl-(2,2-diethoxyethyl)amine

溶剂

MeTHF

反应条件

后处理

1. 1
   温度cooled to 0° C
2. 2
   workup.STIRRINGthe reaction mixture was stirred for 2 h
3. 3
   温度cooled to 0° C
4. 4
   洗涤The organic layer was washed with brine in water (1:1, 2×1 L)
5. 5
   workup.ADDITIONMeTHF (1 L) was added

实验过程

To a mixture of 2,2-diethoxyethylamine (209 mL, 1.43 mol) and MeTHF (1050 L) was added cyclohexanecarbaldehyde (107 mL, 0.89 mol). The reaction mixture was stirred for 30 min at room temperature and cooled to 0° C. Sodium triacetoxyborohydride (378 g, 1.79 mol) was added over 40 min and the reaction mixture was stirred for 2 h and cooled to 0° C. 1 M NaOH (1 L) was added. The organic layer was washed with brine in water (1:1, 2×1 L) and the volume was reduced to ˜20%. MeTHF (1 L) was added and the volume reduced to ˜20%. The solution of the crude title intermediate was used directly in the next step.

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