反应 #710537

反应方程式

Monomethyl fumarate

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

4-Morpholin-4-yl-butan-1-ol

→

title compound

Methyl 4-morpholin-4-ylbutyl (2E)but-2-ene-1,4-dioate

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他After the completion of the reaction

实验过程

Monomethyl fumarate (MMF) was reacted with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDAC) (1.2 eq) in dichloromethane (DCM) at ca. 0° C. 4-Morpholin-4-yl-butan-1-ol (1 eq) and 4-N,N-dimethylaminopyridine (DMAP) (catalytic amount) were added to the activated carboxylic acid. After the completion of the reaction, followed by the work-up of the reaction mixture, the title compound was isolated as a viscous-oil.

来源