反应 #710503

ord-09beeee2505841458329c4dc2d85ed28

反应方程式

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate
→
O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
Sodium Citrate Citric Acid

反应物

O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
O=C([O-])O.[Na+]
sodium bicarbonate

试剂

无

溶剂

O
water
O
water

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他reaction
  2. 2
    其他for the reaction
  3. 3
    其他Carbon dioxide is evaporated rapidly
  4. 4
    其他water is gradually evaporated
  5. 5
    workup.ADDITIONa mixture of 87% Sodium citrate and 13% citric acid active ingredient
  6. 6
    其他The product is then dried
  7. 7
    其他crushed to fine particles
  8. 8
    其他to produce an active composition suitable for formulation into the pharmacological formulations of this invention

实验过程

Mix one part citric acid and one part sodium bicarbonate than gradually spray sterile water into the mixture to make reaction. The water is merely the medium for the reaction. Carbon dioxide is evaporated rapidly and water is gradually evaporated. The remaining product is a mixture of 87% Sodium citrate and 13% citric acid active ingredient. The product is in the form of crystals. The product is then dried and crushed to fine particles to produce an active composition suitable for formulation into the pharmacological formulations of this invention.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US09301935B2uspto-grants-2016_04