反应 #710475

反应方程式

2-aminopyridine

EDC-HCl

chlorodifluoroacetic acid

→

2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide

收率 24.0%

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   洗涤washed with water and 1% hydrochloric acid
2. 2
   干燥dried over anhydrous magnesium sulfate

实验过程

200 mg (2.13 mmol) of 2-aminopyridine was dissolved in 5 ml of dichloromethane, 491 mg (2.55 mmol) of EDC-HCl, 311 mg (2.55 mmol) of DMAP and 187 μl (2.23 mmol, 290 mg) of chlorodifluoroacetic acid were added thereto in sequence, and the resulting mixture was stirred overnight. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed with water and 1% hydrochloric acid, and then dried over anhydrous magnesium sulfate to obtain 105 mg (yield 24%) of 2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide.

来源