反应 #710473

反应方程式

difluoroacetic acid

EDC-HCl

2-aminopyridine

→

2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide

收率 14.0%

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   洗涤washed once with water and twice with a 1% HCl aqueous solution
2. 2
   干燥dried over anhydrous magnesium sulfate
3. 3
   浓缩concentrated under reduced pressure

实验过程

400 mg (4.26 mmol) of 2-aminopyridine was dissolved in 10 ml of anhydrous dichloromethane, 322 μl (490 mg, 5.11 mmol) of difluoroacetic acid, 982 mg (5.10 mmol) of EDC-HCl and 622 mg (5.11 mmol) of DMAP were added thereto, and the resulting mixture was stirred at room temperature for 61 hours. After the reaction was completed, the reaction solution was diluted with dichloromethane, washed once with water and twice with a 1% HCl aqueous solution, and then dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 102 mg (yield 14%) of 2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide.

来源