反应 #70638

反应方程式

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate

HCl

→

1-(trifluoromethyl)cyclopropylamine hydrochloride

收率 91.0%

反应条件

后处理

1. 1
   温度at reflux for 3.5 h
2. 2
   浓缩The solution was concentrated in vacuo
3. 3
   其他the residue was triturated with acetone
4. 4
   其他The filtrate was collected
5. 5
   浓缩concentrated
6. 6
   其他the residue triturated with diethyl ether

实验过程

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (4.08 g, 18.3 mmol) was suspended in 1 N HCl(aq) (150 mL) and stirred at reflux for 3.5 h. The solution was concentrated in vacuo and the residue was triturated with acetone. The filtrate was collected, concentrated, and the residue triturated with diethyl ether to afford 2.67 g (91%) of 1-(trifluoromethyl)cyclopropylamine hydrochloride as a white solid.

来源