反应 #7054

反应方程式

carbon monoxide

5-bromothiophene-2-sulfonamide

triethyl amine

1,3-bis(diphenylphosphino) propane

ethyl acetate

→

title compound

5-(Methoxycarbonyl)thiophene-2-sulfonamide

溶剂

methanol

dimethylformamide

brine

反应条件

后处理

1. 1
   其他The organic phase is separated
2. 2
   萃取the aqueous layer is extracted with 10 mL ethyl acetate
3. 3
   干燥The combined organic layers are dried over sodium sulfate
4. 4
   浓缩concentrated in vacuo
5. 5
   其他chromatographed on silica (0–1% methyl alcohol in methylene chloride)

实验过程

A mixture of 5-bromothiophene-2-sulfonamide (0.50 g, 2.1 mmol), triethyl amine (1 mL), methanol (1 mL), palladium acetate (0.046 g, 2.1 mmol) and 1,3-bis(diphenylphosphino) propane (0.085 g, 2.1 mmol) (addition in that order) in dimethylformamide (5 mL, anhydrous) is saturated with carbon monoxide gas, at room temperature. This reaction mixture is heated to 100° C. and stirred overnight, under a carbon monoxide atmosphere. 10 mL of brine and 10 mL of ethyl acetate are added to the reaction mixture. The organic phase is separated and the aqueous layer is extracted with 10 mL ethyl acetate. The combined organic layers are dried over sodium sulfate, concentrated in vacuo, and then chromatographed on silica (0–1% methyl alcohol in methylene chloride) to give the title compound, as a yellow solid (0.15 g, 34% yield).

来源