反应 #70512

反应方程式

3-[4-(1H-Indol-3-yl)-piperidine-1-carbonyl]-benzonitrile

NaOH

tetrabutyl ammonium hydroxide

4-fluoro-benzyl bromide

→

3-{4-[1-(4-Fluoro-benzyl)-1H-indol-3-yl]-piperidine-1-carbonyl}-benzonitrile

溶剂

THF

反应条件

后处理

1. 1
   其他The layers are separated
2. 2
   其他the organic solvent is removed under the reduced pressure
3. 3
   其他purified by a silica gel flash column

实验过程

3-[4-(1H-Indol-3-yl)-piperidine-1-carbonyl]-benzonitrile (0.08 g, 0.24 mmol) is dissolved in 2 ml THF, then 2 ml of 50% NaOH, 0.2 ml tetrabutyl ammonium hydroxide (1.0M in MeOH), 4-fluoro-benzyl bromide (0.055 g, 0.29 mmol) are added and the reaction mixture is stirred at RT for 1.5 hours. The layers are separated and the organic solvent is removed under the reduced pressure, purified by a silica gel flash column using heptane and ethyl acetate as the elutes.

来源