反应 #702667

反应方程式

ethyl salicylate

stearoyl chloride

triethylamine

→

title product

收率 95.2%

Ethyl 2-(octadecanoyloxy)benzoate

收率 95.2%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   温度After refluxing for 20 hours
2. 2
   其他Most of the tetrahydrofuran was removed with a N2 stream during the cooling process
3. 3
   workup.ADDITIONThe residue was poured into ice/water (1500 ml)
4. 4
   其他a white solid removed by filtration
5. 5
   洗涤Washing the solid with water
6. 6
   其他drying

实验过程

To a cold (+5° C.) solution of ethyl salicylate (0.136 moles) and stearoyl chloride (0.136 moles) in tetrahydrofuran (200 ml) was added triethylamine (0.136 moles) dropwise over 25 min. After refluxing for 20 hours, the solution was cooled to room temperature. Most of the tetrahydrofuran was removed with a N2 stream during the cooling process. The residue was poured into ice/water (1500 ml), stirred for 1 hour, and a white solid removed by filtration. Washing the solid with water, followed by air drying gave 56 g of the title product, m.p. 50.5°-53.5° C.

来源