反应 #702087

反应方程式

6,7-Dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2(3H)-one

hydrochloric acid

Darco

→

6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one Monohydrochloride Monohydrate

溶剂

methanol

反应条件

后处理

1. 1
   workup.ADDITIONTo the suspension was added 77 ml
2. 2
   其他A nearly complete solution resulted
3. 3
   过滤filtered
4. 4
   温度cooled slightly
5. 5
   workup.ADDITION1.9 liters of ether added cautiously
6. 6
   过滤the solid was filtered off

实验过程

6,7-Dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2(3H)-one (94.0 g, 0.367 mol) was added to 2.82 liters of boiling methanol. To the suspension was added 77 ml. (0.92 mol) of concentrated hydrochloric acid. A nearly complete solution resulted. Darco G-60 was added, the mixture was boiled for ca. 3 minutes and then filtered. The filtrate was reheated to boiling to effect solution, then cooled slightly, and 1.9 liters of ether added cautiously. The mixture was stirred at ambient temperature for 2 hours and the solid was filtered off. (Crop A).

来源