反应 #69700

反应方程式

(2,4-bis-benzyloxy-5-isopropyl-phenyl)-(5-hydroxy-1,3-dihydro-isoindol-2-yl)-methanone

2-dimethylaminoethylchloride

HCl

K2CO3

→

title compound

(2,4-bis-benzyloxy-5-isopropyl-phenyl)-[5-(2-dimethylamino-ethoxy)-1,3-dihydro-isoindol-2-yl]-methanone

溶剂

EtOAc

DMF

反应条件

后处理

1. 1
   workup.ADDITIONDilute
2. 2
   过滤filtered
3. 3
   workup.ADDITIONThe reaction mixture was diluted with EtOAc
4. 4
   过滤filtered
5. 5
   其他purified by flash column chromatography
6. 6
   洗涤eluting 100% DCM

实验过程

A mixture of (2,4-bis-benzyloxy-5-isopropyl-phenyl)-(5-hydroxy-1,3-dihydro-isoindol-2-yl)-methanone (100 mg, 0.2 mmol), 2-dimethylaminoethylchloride.HCl (72 mg, 0.5 mmol) and K2CO3 (173 mg, 1.25 mmol) in DMF (5 ml) was heated at 90° C. for 16 hours. Dilute reaction mixture with EtOAc and filtered. The reaction mixture was diluted with EtOAc and filtered. The filtrate was reduced in vacuo and purified by flash column chromatography, eluting 100% DCM then 90% DMAW 90 to give the title compound as an off white gel (79 mg). MS: [M+H]+ 565

来源