反应 #696703

反应方程式

4-Vinylbenzyl chloride

Ethyl acetoacetate

sodium ethoxide

→

ethyl 2-(4-vinylbenzyl)-3-oxobutanoate

收率 95.0%

溶剂

ethanol

反应条件

后处理

1. 1
   温度was cooled in an ice-water bath
2. 2
   温度The mixture was refluxed for 16 hours
3. 3
   过滤the resulting slurry was filtered
4. 4
   其他to remove any salt
5. 5
   其他the solution collected
6. 6
   其他The solvent was removed under reduced pressure

实验过程

Ethyl acetoacetate (27.61 g, 0.21 mol) was dissolved in ethanol (100 ml) which was cooled in an ice-water bath, and sodium ethoxide (15.59 g, 0.22 mol) was added. 4-Vinylbenzyl chloride (33.92 g, 0.2 mole) was added. The mixture was refluxed for 16 hours, then the resulting slurry was filtered to remove any salt, and the solution collected. The solvent was removed under reduced pressure to give ethyl 2-(4-vinylbenzyl)-3-oxobutanoate in the form of a light red liquid (49 g) in 95% yield.

来源