反应 #69632

反应方程式

ammonium chloride

ethanol

2,3-dichloro-6-nitrobenzaldehyde

sodium borohydride

→

2,3-dichloro-6-nitrobenzyl alcohol

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   萃取the solution was extracted three times with EtOAc
2. 2
   干燥The combined organic layers were dried (MgSO4)
3. 3
   浓缩concentrated

实验过程

To a solution of 2,3-dichloro-6-nitrobenzaldehyde (7.62 g, 34.9 mmol) in tetrahydrofuran (75 mL) was added sodium borohydride (1.31 g, 34.9 mmol) followed by ethanol (1.75 mL), and the mixture was stirred for 1.5 hours. Saturated aqueous ammonium chloride (75 mL) was added, and the solution was extracted three times with EtOAc. The combined organic layers were dried (MgSO4) and then concentrated to give 2,3-dichloro-6-nitrobenzyl alcohol, as an oil which crystallised, 7.62 g (98%).

来源