反应 #69128

反应方程式

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate

→

title compound

收率 61.0%

(R)-tert-butyl 1-(4-hydroxycyclohexyl)ethylcarbamate

收率 61.0%

溶剂

methanol

反应条件

后处理

1. 1
   过滤The rhodium catalyst was filtered off
2. 2
   浓缩the mother liquors were concentrated in vacuo
3. 3
   其他The residue was purified on silica gel by flash column chromatography

实验过程

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate (described in the literature: WO 2007035154 (A1)) (100 mg, 0.4214 mmol) was dissolved in methanol (5 mL). A methanolic (5 mL) solution of rhodium on alumina (10 Wt %, 10 mg) was added. The reaction mixture was place under a hydrogen atmosphere and stir at room temperature for 18 hours. The rhodium catalyst was filtered off and the mother liquors were concentrated in vacuo. The residue was purified on silica gel by flash column chromatography to afford the title compound (62 mg, 61% yield).

来源